Methylfolate Matters in Immunity and HPV

Folate, also known as vitamin B9, is an essential nutrient that plays a critical role in many bodily functions, including DNA production, cell division, and immune system regulation. Emerging research suggests folate, particularly in its active form methylfolate, may be a key factor in supporting the immune system's ability to clear human papillomavirus (HPV) infections.

Folate and Immunity

Folate is necessary for the production and maintenance of new cells, including immune cells. It supports the development of white blood cells like neutrophils, lymphocytes and natural killer cells which are vital components of the immune system. Folate deficiency has been associated with impaired immunity and increased susceptibility to infections.

Several studies have demonstrated folate's role in regulating the immune system:

• A 2019 study found folate supplementation enhanced the cytotoxic activity of natural killer cells and T-lymphocytes.

• Another study showed folate deficiency impaired dendritic cell function and reduced T-cell responses. (4)

  Folate and HPV

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  HPV is a common viral infection that can lead to cervical cancer and other cancers in some cases. The immune system plays a crucial role in clearing HPV infections and preventing cancer development.

Some research suggests folate status may influence HPV infection and cervical cancer risk:

• Another study found women with higher folate intake had a lower risk of HPV persistence.

The exact mechanisms are unclear, but folate may support HPV clearance by enhancing the activity of the immune response against HPV-infected cells. Folate is also necessary for proper DNA methylation, which is regulates the expression of genes and could influence the interaction of the immune system with HPV.

Methylfolate - The Active Form

Methylfolate (5-MTHF) is the active, tissue-ready form of folate that can be used by the body without needing to be converted. Some people have genetic variations (like changes in the MTHFR gene) that reduce their ability to convert folic acid into methylfolate. For these individuals, supplementing with methylfolate directly may be more effective.

It is difficult to know if you have these genetic variations and so we suggest taking methylfolate just in case you might not be so efficient at converting folate into methylfolate.

Folate Sources and Dosage

Folate is found naturally in many foods such as leafy greens, legumes, and liver. Folic acid is also added to many refined grain products such as cereals and flour. Methylfolate supplements are also available, typically in doses of 400-1000 mcg/day.

Beef Liver: Amount needed for 1000 mcg: approximately 3.4 servings or 10.2 oz (289g)

Spinach (cooked): Amount needed for 1000 mcg: approximately 7.6 servings or 3.8 cups (684 g)

Black-eyed Peas (cooked): Amount needed for 1000 mcg: approximately 9.5 servings or 4.75 cups (808 g)

Asparagus (cooked): Amount needed for 1000 mcg: approximately 7.5 servings or 30 spears (450 g)

The recommended daily amount for folate is 400 mcg dietary folate equivalents per day for adults and should be easy to get from a well balanced diet. We recommend 1000 mcg/day of methylfolate from supplements and foods while you are on the journey of supporting your immune system to clear HPV.

This information and much more is available to jumpstart your ACTION PLAN in the Navigating High-Risk HPV E-Book now available in our shop.

Safety and Precautions

Folate from foods is not associated with any adverse effects. Folic acid supplements are generally safe at recommended doses, but high doses can cause abdominal cramps, diarrhoea, and potential B12 deficiency masking.

Folate supplements can interact with some medications like methotrexate, sulfasalazine, and anti-epileptic drugs. Consult a doctor before supplementing, especially if you are pregnant, breastfeeding, have a medical condition or take other medications.

In conclusion, folate is an essential vitamin that supports immune function and may play a role in HPV clearance. Getting enough folate from diet or supplements and using methylfolate due to its bioactivity can be a safe and effective way to optimise immunity and potentially reduce the risk of HPV-related cancer. As always, our strategies are meant to be used in conjunction with your conventional medical plan in order to enhance your chances of clearing HPV naturally.

We are here in support of you all the way!

Love,

The HPV Hub and Immuni-P Team

References:

1. Mahmood L. The metabolic processes of folic acid and Vitamin B12 deficiency. J Health Res Rev 2014;1:5-9

2. Courtemanche C, et al. Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol. 2004;173(5):3186-3192.

3. He H, Shui B. Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies. Int J Food Sci Nutr. 2014;65(3):286-292.

4. Flatley JE, et al. Folate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis. Cancer Epidemiol Biomarkers Prev. 2009;18(10):2782-2789.